Events.com apps

How Does a Neuron Decide When and Where to Make a Synapse?

How Does a Neuron Decide When and Where to Make a Synapse?
Image from morningside-alliance.org
Event ended

Featuring P. Robin Hiesinger, PhD, Professor and Head of Neurobiology Division, Institute for Biology, Free University Berlin, Germany
This seminar will be held in the Jerome L. Greene Science Center on Columbia’s Manhattanville campus (9th floor lecture hall). Columbia University’s
Intercampus Shuttle Service
is the best way to travel between campuses. For those unable to attend in person, this seminar will be
livestreamed.
The quest for molecular mechanisms of brain wiring is sturdily guided by the notion of key-and-lock molecules. Yet, most neurons readily form synapses with incorrect partners when given the opportunity. How does this apparent contradiction give rise to the remarkable precision of brain wiring? Brain wiring is a developmental growth process that it not only characterized by precision, but also flexibility and robustness. As in any other growth process, cellular interactions are restricted in space and time. Correspondingly, surface molecular interactions are restricted to those that ‘get to see’ each other during development. This seminar will explore the question how neurons decide when and where to make synapses using the Drosophila visual system as a model. New findings reveal that pattern formation during growth and the kinetics of axonal filopodia restrict synapse formation and partner choice for neurons that are not otherwise prevented from making incorrect synapses in this system. For example, filopodial autophagy restricts inappropriate partner choice through a process of kinetic exclusion that critically contributes to wiring specificity. The seminar will explore this and other neuronal strategies when and where to make synapses during developmental growth that contribute to precise, flexible and robust outcomes in brain wiring.
Those who wish to meet the speaker during their visit should contact
Heike Blockus
(Polleux lab). For general inquiries please contact
programs@zi.columbia.edu
.
The
Columbia Neuroscience Seminar
series is a collaborative effort of
Columbia’s Zuckerman Institute
, the
Department of Neuroscience
, the
Doctoral Program in Neurobiology and Behavior
and the
Columbia Translational Neuroscience Initiative
, and with support from the
Kavli Institute for Brain Science
.

Views - 29/01/2020 Last update
culture
Columbia University – Jerome L. Greene Science Center
605 W. 129th St., New York, 10027, NY, United States
Create an event
Create events for free. They will be immediately recommended to interested users.
Nearby hotels and apartments
605 W. 129th St., New York, 10027, NY, United States
Discover more events in Manhattan
Discover now
Discover more events in Manhattan
Discover now
Columbia University – Jerome L. Greene Science Center
605 W. 129th St., New York, 10027, NY, United States
Create an event
Create events for free. They will be immediately recommended to interested users.
  1. Manhattan
  2. How Does a Neuron Decide When and Where to Make a Synapse?
 
 
 
 
Your changes have been saved.