On Gastric Inhibitory Polypeptide and Fragments
Gastric inhibitory polypeptide (GIP) is an important metabolic hormone in animals.
Gastric inhibitory polypeptide (GIP) is an important metabolic hormone in animals. It has a special molecular structure and plays an important physiological role in animal organisms. GIP is an incretin synthesized and secreted by the enteroendocrine cell-K cells in the upper part of the small intestine of the mammal and is an important member of the gastrointestinal regulatory peptide secretin family. GIP was originally isolated in the pig intestines and inhibits the secretion of gastric acid. The half-life of GIP in plasma is shorter, less than 2 min in mice and 7 and 5 min in normal and type 2 diabetic patients, respectively. The highest concentration in the jejunum and a certain amount of secretion in the duodenum and ileum. Its physiological role is inhibition of gastric acid secretion; inhibition of pepsin secretion; stimulation of insulin release; inhibition of gastric peristalsis and emptying; stimulation of intestinal secretion; stimulation of glucagon secretion.