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ABS Network Lecture: SMART Clinical Trial Design for Tailored Treatment Guidelines

ABS Network Lecture: SMART Clinical Trial Design for Tailored Treatment Guidelines
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SMART Clinical Trial Design for Tailored Treatment Guidelines
Presented by Kelley Kidwell, Ph.D., Associate Professor of Biostatistics, University of Michigan School of Public Health
Lunch will be provided at 11:30. Remarks by Dr. Cathie Spino at 11:50 a.m. and the lecture by Dr. Kidwell will begin promptly at 12:00 p.m.
This talk will introduce sequential, multiple assignment, randomized trial (SMART) design as a tool to build effective, tailored intervention guidelines used for the prevention or treatment of diseases or disorders or for the implementation of best practices
Diseases or disorders such as substance abuse, depression, ADHD, autism, HIV/AIDs, diabetes and cancer require sequences of treatments over time to address changing characteristics of the disease and the patient. These tailored treatment guidelines are known as dynamic treatment regimens (DTRs; also known as adaptive interventions) and are relevant to not only treat, but also to prevent diseases or disorders or implement best practices. DTRs provide guidelines tailored to the individual to elicit overall optimal outcomes. One way to build and compare DTRs is by using a clinical trial called a sequential, multiple assignment, randomized trial (SMART). A SMART is a multi-stage clinical trial where each stage corresponds to a critical decision point and some participants may be re-randomized based on intermediate outcomes. The same participants are followed throughout the trial as they follow a specific DTR. In this talk, we will introduce SMART designs and compare them to standard trial designs, provide guidance on the types of questions that they can address, how to size such trials, and briefly introduce how to analyze a SMART to find evidence for effective DTRs.
Kelley Kidwell is an Associate Professor of Biostatistics. Kelley joined the University of Michigan after she earned her doctoral degree in Biostatistics from the University of Pittsburgh Graduate School of Public Health in 2012. Her research centers on the design and analysis of clinical trials, especially sequential multiple assignment randomized trials. She is interested in many collaborative areas including cancer, mental health, and rare diseases.
We would like to have you join in person, however, if needed, please join us via BlueJeans link.
Our aim is to provide an outstanding experience for all attendees. If you require reasonable accommodations in order to attend, please contact us at least 1 week prior to the event. (Janine Capsouras - jleahcap@umich.edu or 763-1709)

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